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Home - Products - Cell Cycle/DNA Damage - AChR - PHA 543613

PHA 543613

CAS No. 478149-53-0

PHA 543613( —— )

Catalog No. M33906 CAS No. 478149-53-0

PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 104 Get Quote
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Biological Information

  • Product Name
    PHA 543613
  • Note
    Research use only, not for human use.
  • Brief Description
    PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer's disease and schizophrenia.
  • Description
    PHA-543613 is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a Ki of 8.8 nM. PHA-543613 displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors. PHA-543613 can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male CD-1 mice with (intracerebral hemorrhage) ICH-induction or sham surgeryDosage:4 and 12 mg/kg Administration:Intraperitoneal injection; 4 and 12 mg/kg; 1 hour after surgery Result:Increased p-Akt and decreased p-GSK-3 and CC3 expressions in the ipsilateral hemisphere and reduced the neuronal cell death in the perihematomal area. Attenuated behavioral deficits and brain edema at 72 hours after ICH.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    AChR
  • Recptor
    AChR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    478149-53-0
  • Formula Weight
    271.31
  • Molecular Formula
    C15H17N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (921.46 mM; Ultrasonic )H2O : 100 mg/mL (368.58 mM; Ultrasonic)
  • SMILES
    O=C(N[C@H]1CN2CCC1CC2)c1cc2ccoc2cn1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Donn G Wishka, et al. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship. J Med Chem. 2006 Jul 13;49(14):4425-36. ?
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