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Pamoic acid disodium
CAS No. 6640-22-8
Pamoic acid disodium( —— )
Catalog No. M33901 CAS No. 6640-22-8
Pamoic acid disodium is a GPR35 agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 37 | In Stock |
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| 10MG | 29 | In Stock |
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| 25MG | 44 | In Stock |
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| 50MG | 63 | In Stock |
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| 100MG | 88 | In Stock |
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| 200MG | 131 | In Stock |
|
| 500MG | 219 | In Stock |
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| 1G | 322 | In Stock |
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Biological Information
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Product NamePamoic acid disodium
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NoteResearch use only, not for human use.
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Brief DescriptionPamoic acid disodium is a GPR35 agonist.
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DescriptionPamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium potently recruits β-arrestin2 to GPR35 and has an antinociceptive effect.
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In VitroWestern Blot AnalysisCell Line:U2OS cells Concentration:1, 10, 100 nM and 1, 10 μM Incubation Time:15 min Result:A concentration-dependent activation of ERK1/2 was observed with an EC50 of 65 nM.
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In VivoAnimal Model:Swiss-Webster mice (30–35 g)Dosage:25, 50, and 100 mg/kg Administration:Subcutaneous injection, once Result:Elicited dose-related antinociception, the dose causing 50% antinociception being 40.5 mg/kg.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number6640-22-8
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Formula Weight411.36
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Molecular FormulaC23H16NaO6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (231.30 mM; Ultrasonic (<60°C)
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SMILES[Na+].[Na+].Oc1c(cc2ccccc2c1Cc1c(O)c(cc2ccccc12)C([O-])=O)C([O-])=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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PF-543
PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
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ELOVL1-IN-2
ELOVL1-IN-2, a compound known as an inhibitor of the elongation of very long chain fatty acid 1 (ELOVL1) enzyme, exhibits a weak inhibitory effect on ELOVL1 (with an IC50 of 21 μM) and demonstrates moderate potency in a primary cellular assay conducted on HEK293 C26 cells (with an IC50 of 6.7 μM) .
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