Cart
sales@molnova.com
ML 10302 hydrochloride
CAS No. 186826-17-5
ML 10302 hydrochloride( —— )
Catalog No. M33888 CAS No. 186826-17-5
ML 10302 hydrochloride is a specific agonist 5-HT4 and binds 5-HT receptors with Kis of 1.07 nM and 782 nM for 5-HT4 and 5-HT3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 55 | Get Quote |
|
| 10MG | 67 | Get Quote |
|
| 25MG | 141 | Get Quote |
|
| 50MG | 262 | Get Quote |
|
| 100MG | 315 | Get Quote |
|
| 200MG | 441 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameML 10302 hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionML 10302 hydrochloride is a specific agonist 5-HT4 and binds 5-HT receptors with Kis of 1.07 nM and 782 nM for 5-HT4 and 5-HT3.
-
DescriptionML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay.
-
In VitroML 10302 hydrochloride shows Kis of 1.07 nM and 782 nM for 5-HT4 receptor and 5-HT3 receptor, respectively, in binding assay.
-
In VivoML 10302 hydrochloride (20?mg/kg; s.c.) induces the soluble form of amyloid precursor protein (sAPPα) production in the cortex of mice.Animal Model:8-weeks old adult male C57BL/6j wild-type mice (23-27?g)Dosage:5 mg/kg, 10 mg/kg, 20?mg/kg Administration:Subcutaneous injection Result:Significantly increased sAPPα level in the cortex.
-
Synonyms——
-
PathwayGPCR/G Protein
-
Target5-HT Receptor
-
Recptor5-HT Receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number186826-17-5
-
Formula Weight349.25
-
Molecular FormulaC15H22Cl2N2O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCOC1=CC(=C(C=C1C(=O)OCCN2CCCCC2)Cl)N.Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Langlois, M., et al. Design of a potent 5-HT4 receptor agonist with nanomolar affinity. Bioorganic & Medicinal Chemistry Letters. 1994. 4(12), 1433–1436.
molnova catalog
related products
-
(R)-Mirtazapine
(R)-Mirtazapine ((R)-Org3770) is the R(-)-enantiomer of Mirtazapine, exhibiting anti-injury sensory properties in an animal model of acute thermal hyperalgesia.
-
MDL 100907
A potent, selective 5-HT2A receptor antagonist with Ki of 0.36 nM, > 80-fold selectivity for 5-HT2A over other serotonergic receptors.
-
p-MPPF dihydrochlori...
p-MPPF dihydrochloride is a selective 5-HT antagonist that dose-dependently antagonizes hypothermia induced by 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and can be used to study neurological diseases.
