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LP44 hydrochloride

CAS No. 824958-12-5

LP44 hydrochloride( —— )

Catalog No. M33879 CAS No. 824958-12-5

LP44 hydrochloride is a selective and potent 5-HT7 agonist (Ki:0.22 nM).LP44 hydrochloride has analgesic effects on formalin-induced orofacial pain in mice and can be used in the study of neuroinflammation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LP44 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    LP44 hydrochloride is a selective and potent 5-HT7 agonist (Ki:0.22 nM).LP44 hydrochloride has analgesic effects on formalin-induced orofacial pain in mice and can be used in the study of neuroinflammation.
  • Description
    LP44 (hydrochloride) is a selective 5-HT7 agonist with Ki of 0.22 nM. LP44 (hydrochloride) induces hypothermic effect in a dose-dependent manner by intracerebroventricular injection. LP44 (hydrochloride) not causes considerable hypothermic response by intraperitoneal administration.
  • In Vitro
    ——
  • In Vivo
    LP44 (hydrochloride) (5.1, 10.3, 20.5, 41.0 nmol; i.c.v.) produces dose-dependent hypothermic effect in CBA mice.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    824958-12-5
  • Formula Weight
    488.13
  • Molecular Formula
    C27H38ClN3OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (204.86 mM; Ultrasonic )
  • SMILES
    Cl.O=C(NC1C=2C=CC=CC2CCC1)CCCCCN3CCN(C=4C=CC=CC4SC)CC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Naumenko VS,et al. On the role of brain 5-HT7 receptor in the mechanism of hypothermia: comparison with hypothermia mediated via 5-HT1A and 5-HT3 receptor. Neuropharmacology. 2011 Dec;61(8):1360-5.?
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