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(E)-FeCP-oxindole

CAS No. 884338-18-5

(E)-FeCP-oxindole( —— )

Catalog No. M33847 CAS No. 884338-18-5

(E)-FeCP-oxindole is an inhibitor of VEGFR2 with IC50 of 214 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    (E)-FeCP-oxindole
  • Note
    Research use only, not for human use.
  • Brief Description
    (E)-FeCP-oxindole is an inhibitor of VEGFR2 with IC50 of 214 nM.
  • Description
    (Z)-FeCP-oxindole is a selective human vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with an IC50 value of 200 nM. (Z)-FeCP-oxindole can significantly inhibit VEGFR1 and PDGFRa or b at 10 μM. (Z)-FeCP-oxindole has some anticancer activity, acting on B16 murine melanoma lines with IC50 less than 1 μM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    VEGFR
  • Recptor
    VEGFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    884338-18-5
  • Formula Weight
    329.17
  • Molecular Formula
    C19H15FeNO
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(\[C-]12[Fe+2]3456789([CH]1=[CH]3[CH]4=[CH]52)[CH-]%10[CH]6=[CH]7[CH]8=[CH]9%10)=C/%11\C=%12C(NC%11=O)=CC=CC%12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. John Spencer, et al. Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics. 2011 Jun;3(6):600-8.?
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