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PACOCF3

CAS No. 141022-99-3

PACOCF3( —— )

Catalog No. M33771 CAS No. 141022-99-3

PACOCF3 (Palmityltrifluoromethylketone) (Palmityltrifluoromet hylketone) is an inhibitor of Ca(2+)-independent phospholipase A2(PLA2) with an IC 50 of 3.8 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PACOCF3
  • Note
    Research use only, not for human use.
  • Brief Description
    PACOCF3 (Palmityltrifluoromethylketone) (Palmityltrifluoromet hylketone) is an inhibitor of Ca(2+)-independent phospholipase A2(PLA2) with an IC 50 of 3.8 μM.
  • Description
    PACOCF3 (Palmityltrifluoromet hylketone) is a selective phospholipase A2 inhibitor with an IC50 of 3.8 μM. PACOCF3 alters Ca2+ signaling in renal tubular cells.
  • In Vitro
    At a concentration of 20 μM, PACOCF3 does not change basal cytosolic free calcium concentrations ([Ca2+]i), but at concentrations of 50-250 μM PACOCF3 induced an increase in [Ca2+]i by activating extracellular Ca2+ entry which is partly suppressed by 50 μM La3+. The effect of PACOCF3 is abolished by removal of extracellular Ca2+. PACOCF3 (10 μM) enhances both the peak value and the area under the curve of the [Ca2+]i increase induced by 10 μM ATP and 1 μM bradykinin by potentiating extracellular Ca2+ influx without affecting internal Ca2+ release.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phospholipase
  • Recptor
    Phospholipase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    141022-99-3
  • Formula Weight
    308.42
  • Molecular Formula
    C17H31F3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 33.33 mg/mL (108.07 mM; Ultrasonic )
  • SMILES
    CCCCCCCCCCCCCCCC(=O)C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. E J Ackermann, et al. Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem. 1995 Jan 6;270(1):445-50. ?
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