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MMPSI
CAS No. 220509-74-0
MMPSI( —— )
Catalog No. M33769 CAS No. 220509-74-0
MMPSI (Caspase-3/7 Inhibitor I) is a novel, non-peptide small molecule caspase 3 and caspase 7 inhibitor that reduces ischemic injury in isolated rabbit heart or cardiomyocytes and inhibits apoptosis of H16c2 cells in a concentration-dependent manner.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 312 | In Stock |
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| 10MG | 502 | In Stock |
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| 25MG | 937 | In Stock |
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| 50MG | 1451 | In Stock |
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| 100MG | 2251 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMMPSI
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NoteResearch use only, not for human use.
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Brief DescriptionMMPSI (Caspase-3/7 Inhibitor I) is a novel, non-peptide small molecule caspase 3 and caspase 7 inhibitor that reduces ischemic injury in isolated rabbit heart or cardiomyocytes and inhibits apoptosis of H16c2 cells in a concentration-dependent manner.
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DescriptionMMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC50 of 1.7 μM for human caspase-3. MMPSI can significantly reduce ischemia-reperfusion-induced infarct size in the isolated rabbit heart, and reduce apoptosis in both the ischemic myocardium and isolated cardiomyocytes. MMPSI can be used for researching cardioprotection.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetCaspase
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RecptorCaspase | Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number220509-74-0
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Formula Weight324.35
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Molecular FormulaC14H16N2O5S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (308.31 mM; Ultrasonic )
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SMILESO=C1C=2C(=CC=C(S(=O)(=O)N3[C@H](COC)CCC3)C2)NC1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chapman JG, et al, Tracey WR. A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury. Eur J Pharmacol. 2002;456(1-3):59-68.?
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