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Home - Products - Proteasome/Ubiquitin - Endogenous Metabolite - Tetrahydrofolic acid

Tetrahydrofolic acid

CAS No. 135-16-0

Tetrahydrofolic acid( —— )

Catalog No. M33723 CAS No. 135-16-0

Tetrahydrofolic acid (5,6,7,8-tetrahydrofolic acid) is a vitamin B9 derivative that is a common one-carbon donor in organisms and is involved in growth and metabolism.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Tetrahydrofolic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    Tetrahydrofolic acid (5,6,7,8-tetrahydrofolic acid) is a vitamin B9 derivative that is a common one-carbon donor in organisms and is involved in growth and metabolism.
  • Description
    Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid.
  • In Vitro
    Cell Viability Assay Cell Line:Adh5-/- DT40 cells Concentration:0-200 μM Incubation Time:3 days Result:Viability of Adh5-/- DT40 cells rapidly dropped. Western Blot Analysis Cell Line:Adh5-/- DT40 cells Concentration: 0-200 μM Incubation Time:16 hours Result:Strongly promoted FANCD2 and ser139-H2AX focus formation in Adh5-/- cells in a dose-dependent manner.
  • In Vivo
    Animal Model:Adh5-/- mice Dosage:62.5 mg/kg Administration:Intraperitoneal injection; daily Result:Perturbed hematopoiesis, increased ser139-H2AX phosphorylation, and decreased the survival of progenitor cells (HSPCs).
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    Endogenous Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    135-16-0
  • Formula Weight
    445.43
  • Molecular Formula
    C19H23N7O6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 20.83 mg/mL (46.76 mM; Ultrasonic )
  • SMILES
    Nc1nc2NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Nc2c(=O)[nH]1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Clara B García-Calderón, et al. Genotoxicity of Tetrahydrofolic Acid to Hematopoietic Stem and Progenitor Cells. Cell Death Differ. 2018 Nov;25(11):1967-1979.?
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