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7α,25-Dihydroxycholesterol
CAS No. 64907-22-8
7α,25-Dihydroxycholesterol( 7α,25-OHC )
Catalog No. M22488 CAS No. 64907-22-8
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2], and it is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
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| 25MG | 758 | In Stock |
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| 50MG | 1160 | In Stock |
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| 100MG | Get Quote | In Stock |
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Biological Information
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Product Name7α,25-Dihydroxycholesterol
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NoteResearch use only, not for human use.
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Brief Description7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2], and it is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM).
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Description7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells, and it is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). In vitro, 7α, 25-dihydroxycholesterol (7α,25-OHC) stimulates the migration of EBI2-expressing mouse B and T cells with half-maximum effective concentration values around 500 pM. but it had no effect on EBI2-deficient cells[1].EBI2-deficient B cells or normal B cells desensitized by 7α,25-Dihydroxycholesterol (1 μM; 1.5 hours) pre-treatment shows reduced homing to follicular areas of the spleen.
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In Vitro——
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In Vivo——
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Synonyms7α,25-OHC
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PathwayProteasome/Ubiquitin
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TargetEndogenous Metabolite
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RecptorHuman Endogenous Metabolite|GPR183
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Research Area——
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Indication——
Chemical Information
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CAS Number64907-22-8
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Formula Weight418.65
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Molecular FormulaC27H46O3
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Purity>98% (HPLC)
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SolubilityDMSO:1 mg/mL?(2.39 mM;?Need ultrasonic)
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SMILES[H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CCCC(C)(C)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Taurodeoxycholate so...
Taurodeoxycholate sodium salt is a bile salt-related anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins. and it inhibits various inflammatory responses
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H-Leu-Leu-OMe HBr
H-Leu-Leu-OMe HBr (L-Leucyl-L-Leucine methyl ester HBr) is a dipeptide condensation product of L-Leucine methyl ester, a peptide that is toxic to natural killer T-cells and possesses immunosuppressive activity that abrogates all natural killer (NK) cell functions in mixed lymphocyte populations.
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L-(-)-Malic acid
Malic acid is a tart-tasting organic dicarboxylic acid that plays a role in many sour or tart foods. Apples contain malic acid which contributes to the sourness of a green apple. Malic acid can make a wine taste tart although the amount decreases with increasing fruit ripeness.
