7-Hydroxymethotrexate( —— )

Catalog No. M33666 CAS No. 5939-37-7

7-Hydroxymethotrexate is the major metabolite of Methotrexate.Methotrexate is an inhibitor of folic acid, inhibiting dihydrofolate reductase, which prevents the conversion of folic acid to tetrahydrofolate, and inhibiting DNA synthesis.

Purity : >98% (HPLC)

COA

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Biological Information

Product Name

7-Hydroxymethotrexate
Note

Research use only, not for human use.
Brief Description

7-Hydroxymethotrexate is the major metabolite of Methotrexate.Methotrexate is an inhibitor of folic acid, inhibiting dihydrofolate reductase, which prevents the conversion of folic acid to tetrahydrofolate, and inhibiting DNA synthesis.
Description

7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
In Vitro

7-Hydroxymethotrexate (7-OHMTX) has the affinity of DHFR markedly lower (>100-fold) than for Methotrexate (MTX) .
In Vivo

7-Hydroxymethotrexate (4 mg/kg; IV) has a terminal half-life of 97.2 min and a total clearance value of 9.6 mL/min?mg.Animal Model:Male Wistar rats (270-440 g)Dosage:4 mg/kg (Pharmacokinetic Analysis)Administration:IVResult:Had a terminal half-life of 97.2 min and a total clearance value of 9.6 mL/min?mg.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Drug Metabolite
Research Area

——
Indication

——

Chemical Information

CAS Number

5939-37-7
Formula Weight

470.44
Molecular Formula

C20H22N8O6
Purity

>98% (HPLC)
Solubility

——
SMILES

NC1=C2C(NC(=O)C(CN(C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=NC(N)=N1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. L Fahrig, et al. Pharmacokinetics of methotrexate (MTX) and 7-hydroxymethotrexate (7-OH-MTX) in rats and evidence for the metabolism of MTX to 7-OH-MTX. Cancer Chemother Pharmacol. 1989;23(3):156-60.?

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