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Ac-YVAD-CHO
CAS No. 143313-51-3
Ac-YVAD-CHO( —— )
Catalog No. M33640 CAS No. 143313-51-3
Ac-YVAD-CHO (L 709049) is a selective and potent tetrapeptide interleukin 1β-converting enzyme (ICE) and caspase-1 (ICE)-like protease inhibitor with anti-inflammatory activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 275 | In Stock |
|
| 10MG | 407 | In Stock |
|
| 25MG | 663 | In Stock |
|
| 50MG | 900 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameAc-YVAD-CHO
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NoteResearch use only, not for human use.
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Brief DescriptionAc-YVAD-CHO (L 709049) is a selective and potent tetrapeptide interleukin 1β-converting enzyme (ICE) and caspase-1 (ICE)-like protease inhibitor with anti-inflammatory activity.
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DescriptionAc-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a caspase-1 inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ.
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In VitroWestern Blot Analysis Cell Line:SNAP-treated thymocytes Concentration:15.6 μM Incubation Time:12 h Result:Reduced PARP cleavage.
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In VivoAnimal Model:P. acnes-sensitized miceDosage:50 mg/kg Administration:I.p.; Result: Suppressed IL-1β levels in blood.Animal Model:Quinolinic acid-treated RatsDosage:2-8 μg Administration:Intrastriatal infusion. Result:Attenuated Quinolinic acid (QA)-induced increases in p53 and apoptosis in rat striatum.Inhibited QA-induced increases in caspase-1 activity and p53 protein levels, with no effect on QA-induced IκB-α degradation, NF-κB or AP-1 activation.
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Synonyms——
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PathwayApoptosis
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TargetCaspase
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RecptorCaspase | Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number143313-51-3
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Formula Weight492.52
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Molecular FormulaC23H32N4O8
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : ≥ 50 mg/mL (101.52 mM)* "≥" means soluble, but saturation unknown.
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SMILES[C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC(C)=O)=O)(C(N[C@H](C(N[C@@H](CC(O)=O)C=O)=O)C)=O)C(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fletcher DS, et al. A synthetic inhibitor of interleukin-1 beta converting enzyme prevents endotoxin-induced interleukin-1 beta production in vitro and in vivo. J Interferon Cytokine Res. 1995;15(3):243-248.?
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