Triciribine phosphate( —— )

Catalog No. M33627 CAS No. 61966-08-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Triciribine phosphate
Note

Research use only, not for human use.
Brief Description

Triciribine phosphate (VD 002) is a highly selective AKT inhibitor that induces cell cycle arrest and cysteinyl asparagin-dependent apoptosis, inhibits neovascularization, and can be used in the study of leukemia.
Description

Triciribine phosphate (TCN-P) inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate also inhibits IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Akt
Recptor

Akt | Apoptosis
Research Area

——
Indication

——

CAS Number

61966-08-3
Formula Weight

400.28
Molecular Formula

C13H17N6O7P
Purity

>98% (HPLC)
Solubility

——
SMILES

NC=1C=2C=3C(N(C2)[C@@H]4O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]4O)=NC=NC3N(C)N1
Chemical Name

——

1. E C Moore, Inhibition of two enzymes in de novo purine nucleotide synthesis by triciribine phosphate (TCN-P). Biochem Pharmacol. 1989, 38, 22.?

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