Dehydroglyasperin C

Research use only, not for human use.

Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities.

Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protective effects against chronic diseases caused by reactive oxygen species as well as potential as an antioxidant food additive.

Dehydroglyasperin C (0.1-1 μM; 24 h) blocks the PDGF-induced progression through the G0/G1 to S phase of the cell cycle, and down-regulates the expression of CDK; 2, cyclin E, CDK4 and cyclin D1. Dehydroglyasperin C significantly attenuates PDGF-stimulated phosphorylation of PDGF receptor-β, phospholipase C-γ1, AKT and extracellular-regulated kinase 1/2, and DGC inhibits cell migration and the dissociation of actin filaments by PDGF.Dehydroglyasperin C (0.1-1 μM; 24 h) treatment significantly decreases PDGF-induced cell number and DNA synthesis in a dose-dependent manner without any cytotoxicity in human aortic smooth muscle cells (HASMC).Cell Cycle Analysis Cell Line:Human aortic smooth muscle cells (HASMC) Concentration:0.1 μM, 0.5 μM, 1 μM Incubation Time:24 hours Result:Blocked the PDGF-induced progression through the G0/G1 to S phase of the cell cycle.Western Blot Analysis Cell Line:Human aortic smooth muscle cells (HASMC) Concentration:0.1 μM, 0.5 μM, 1 μM Incubation Time:24 hours Result:Down-regulated the expression of CDK; 2, cyclin E, CDK4 and cyclin D1.

In ICR mice, Dehydroglyasperin C (5 mg/kg; once) combined with CCl4 shows reduced lipid droplet formation in liver tissue, as assessed by histological examination. Further, DGC demonstrated a slight protective effect against centrilobular injury caused by CCl4 injection, perhaps through suppression of CYP2E1 expression.

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Cytoskeleton/Cell Adhesion Molecules

Akt

Akt;AP-1;COX;ERK;HO-1;IkB;IKK;JNK;NADPH;NF-κB;Nrf2;p38 MAPK;p65;PI3K;TNF-α

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199331-35-6

354.4

C21H22O5

>98% (HPLC)

DMSO : 100 mg/mL (282.17 mM; ultraphonic; )

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(-20℃)

With Ice Pack

≥ 2 years