MK-0674( —— )

Catalog No. M33431 CAS No. 887781-62-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MK-0674
Note

Research use only, not for human use.
Brief Description

MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabolism-related diseases.
Description

MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S.
In Vitro

MK-0674 (Compound 13) is potent in bone resorption in rabbit osteoclasts, with an IC50 of 10 nM.
In Vivo

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Synonyms

——
Pathway

Proteasome/Ubiquitin
Target

Cysteine Protease
Recptor

Cysteine Protease
Research Area

——
Indication

——

CAS Number

887781-62-6
Formula Weight

527.5
Molecular Formula

C26H27F6N3O2
Purity

>98% (HPLC)
Solubility

——
SMILES

N(C([C@@H](N[C@H]([C@](F)(F)F)C1=CC=C(C=C1)C2=CC=C([C@H](C(F)F)O)C=C2)CC(C)(C)F)=O)C3(C#N)CC3
Chemical Name

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1. Isabel E, et al. The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor. Bioorg Med Chem Lett. 2010 Feb 1;20(3):887-92.?

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