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Managlinat dialanetil

CAS No. 280782-97-0

Managlinat dialanetil( —— )

Catalog No. M33426 CAS No. 280782-97-0

Managlinat dialanetil (MB06322) is an orally available and potent fructose 1,6-bisphosphatase (FBPase) inhibitor with hypoglycaemic activity for the study of type 2 diabetes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Managlinat dialanetil
  • Note
    Research use only, not for human use.
  • Brief Description
    Managlinat dialanetil (MB06322) is an orally available and potent fructose 1,6-bisphosphatase (FBPase) inhibitor with hypoglycaemic activity for the study of type 2 diabetes.
  • Description
    Managlinat dialanetil (MB06322) is an orally bioavailable inhibitor of fructose 1,6-bisphosphatase (FBPase) for the treatment of type 2 diabetes .
  • In Vitro
    ——
  • In Vivo
    Managlinat dialanetil dose-dependently inhibits GNG as well as lower basal and postprandial blood glucose levels in Zucker diabetic fatty (ZDF) rats after oral administration.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phosphatase
  • Recptor
    Phosphatase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    280782-97-0
  • Formula Weight
    500.55
  • Molecular Formula
    C21H33N4O6PS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (49.95 mM; Ultrasonic )
  • SMILES
    C(C(C)C)C1=C(N=C(N)S1)C=2OC(P(N[C@H](C(OCC)=O)C)(N[C@H](C(OCC)=O)C)=O)=CC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang Y, et al. Managlinat dialanetil, a fructose-1,6-bisphosphatase inhibitor for the treatment of type 2 diabetes. Curr Opin Investig Drugs. 2007 Oct;8(10):849-58.?
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