LP-922761

Research use only, not for human use.

LP-922761 is a potent, selective, and orally active AAK1 inhibitor with inhibitory effects on BMP-2 induced protein kinase (BIKE).

LP-922761 is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively.LP-922761 also inhibits BMP-2-inducible protein kinase (BIKE) with an IC50 of 24 nM. LP-922761 exhibits no significant activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors.

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Others

Other Targets

AAK1 (AP2 associated kinase 1)

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1454808-95-7

410.47

C21H26N6O3

>98% (HPLC)

In Vitro:?DMSO : 41.67 mg/mL (101.52 mM; Ultrasonic (<80°C)

CN(CCNc1ccc2ncc(-c3ccc(cc3)C(N)=O)n2n1)C(=O)OC(C)(C)C

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(-20℃)

With Ice Pack

≥ 2 years