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LP-922761
CAS No. 1454808-95-7
LP-922761( —— )
Catalog No. M33411 CAS No. 1454808-95-7
LP-922761 is a potent, selective, and orally active AAK1 inhibitor with inhibitory effects on BMP-2 induced protein kinase (BIKE).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 72 | In Stock |
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| 5MG | 123 | In Stock |
|
| 10MG | 202 | In Stock |
|
| 25MG | 363 | In Stock |
|
| 50MG | 528 | In Stock |
|
| 100MG | 756 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLP-922761
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NoteResearch use only, not for human use.
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Brief DescriptionLP-922761 is a potent, selective, and orally active AAK1 inhibitor with inhibitory effects on BMP-2 induced protein kinase (BIKE).
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DescriptionLP-922761 is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively.LP-922761 also inhibits BMP-2-inducible protein kinase (BIKE) with an IC50 of 24 nM. LP-922761 exhibits no significant activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorAAK1 (AP2 associated kinase 1)
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Research Area——
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Indication——
Chemical Information
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CAS Number1454808-95-7
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Formula Weight410.47
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Molecular FormulaC21H26N6O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 41.67 mg/mL (101.52 mM; Ultrasonic (<80°C)
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SMILESCN(CCNc1ccc2ncc(-c3ccc(cc3)C(N)=O)n2n1)C(=O)OC(C)(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.?
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