Chlorhexidine digluconate( —— )

Catalog No. M33315 CAS No. 18472-51-0

Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant with broad-spectrum antimicrobial activity, inhibits both Gram-positive and Gram-negative bacteria, induces necrosis and apoptosis, and can be used in the study of bacterial infections.

Purity : >98% (HPLC)

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Biological Information

Product Name

Chlorhexidine digluconate
Note

Research use only, not for human use.
Brief Description

Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant with broad-spectrum antimicrobial activity, inhibits both Gram-positive and Gram-negative bacteria, induces necrosis and apoptosis, and can be used in the study of bacterial infections.
Description

Chlorhexidine digluconate is a chlorophenyl biguanide with broad antibacterial action against both Gram (+) and (-) bacteria and fungi. Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant. Chlorhexidine digluconate is effective to prevent and control infectious diseases of the mouth by killing bacteria in saliva and tongue. Chlorhexidine digluconate is a cytotoxic agent and induces cell necrosis and apoptosis.
In Vitro

Cell Cytotoxicity Assay Cell Line:Chinese hamster ovary cells Concentration:0.00001%, 0.00005%, 0.0001%, 0.0005% Incubation Time:1, 2, 4 h Result:Demonstrated a cytotoxic effect on CHO cells.Apoptosis Analysis Cell Line:Chinese hamster ovary cells Concentration:0.00005%, 0.0001%, 0.0005% Incubation Time:1 h Result:After a 1 hour treatment, the amount of cell apoptosis was about 1.62%, 5.51%, and 5.47%, respectively. The amount of cell necrosis was 2.38%, 8.62%, and 22.50%, respectively.
In Vivo

Model:Male Imprinting Control Region (ICR) mice at 6 to 8-wk-old (body weight, 25g)Dosage:Chlorhexidine gluconate 0.05% and 0.025% Administration:One-time intraperitoneal injection Result:With 0.05% lavage had significantly lower incidence of postoperative intra-abdominal abscesses compared with the mice that had saline lavage only.
Synonyms

——
Pathway

Apoptosis
Target

Apoptosis
Recptor

Apoptosis | Antibiotic
Research Area

——
Indication

——

Chemical Information

CAS Number

18472-51-0
Formula Weight

897.76
Molecular Formula

C34H54Cl2N10O14
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 100 mg/mL (111.39 mM; Ultrasonic) DMSO : ≥ 38 mg/mL (42.33 mM)
SMILES

ClC(C=C1)=CC=C1NC(NC(NCCCCCCNC(NC(NC2=CC=C(C=C2)Cl)=N)=N)=N)=N.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Wael E Shams, et al. Peritoneal Lavage Using Chlorhexidine Gluconate at the End of Colon Surgery Reduces Postoperative Intra-Abdominal Infection in Mice. J Surg Res. 2015 May 1;195(1):121-7.?

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