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JWG-071
CAS No. 2250323-50-1
JWG-071( —— )
Catalog No. M33288 CAS No. 2250323-50-1
JWG-071, the first reported chemical probe for ERK5 kinase selectivity, is a BET-selective inhibitor with a 1 μM BRD4 IC that enhances both ERK5 activity and BRD4 selectivity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 84 | In Stock |
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| 2MG | 38 | In Stock |
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| 5MG | 61 | In Stock |
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| 10MG | 101 | In Stock |
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| 25MG | 202 | In Stock |
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| 50MG | 346 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJWG-071
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NoteResearch use only, not for human use.
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Brief DescriptionJWG-071, the first reported chemical probe for ERK5 kinase selectivity, is a BET-selective inhibitor with a 1 μM BRD4 IC that enhances both ERK5 activity and BRD4 selectivity.
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DescriptionJWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 improves ERK5 activity and BRD4 selectivity. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology.
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In VitroJWG-071 inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively.
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetEpigenetic Reader Domain
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RecptorEpigenetic Reader Domain | ERK
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Research Area——
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Indication——
Chemical Information
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CAS Number2250323-50-1
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Formula Weight612.77
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Molecular FormulaC34H44N8O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (163.20 mM; Ultrasonic )
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SMILESCCC(C)N1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(cc3OC)C(=O)N3CCC(CC3)N3CCN(C)CC3)nc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang J, et al. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinonesas Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448?
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