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ALX-1393
CAS No. 949164-09-4
ALX-1393( —— )
Catalog No. M33260 CAS No. 949164-09-4
ALX-1393 is a selective GlyT2 inhibitor that effectively reduces neuronal action potential activity in a concentration-dependent manner and inhibits the activity of spontaneous networks by inducing glycinergic tetanic currents in the abdominal horn of the spinal cord.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 2098 | In Stock |
|
| 5MG | 2660 | In Stock |
|
| 10MG | 3591 | In Stock |
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| 25MG | 5170 | In Stock |
|
| 50MG | 6983 | In Stock |
|
| 100MG | 8883 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameALX-1393
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NoteResearch use only, not for human use.
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Brief DescriptionALX-1393 is a selective GlyT2 inhibitor that effectively reduces neuronal action potential activity in a concentration-dependent manner and inhibits the activity of spontaneous networks by inducing glycinergic tetanic currents in the abdominal horn of the spinal cord.
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DescriptionALX-1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model.
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In Vitro——
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In VivoALX1393 (i.c.v.; 25, 50, and 100 μg) in normal rats suppresses the late-phase response in the formalin test but does not affect motor performance. ALX1393 inhibits mechanical and cold hyperalgesia in a dose-dependent manner.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetGlyT
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RecptorGlyT
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Research Area——
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Indication——
Chemical Information
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CAS Number949164-09-4
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Formula Weight395.42
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Molecular FormulaC23H22FNO4
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Purity>98% (HPLC)
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Solubility——
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SMILESC(OC[C@@H](C(O)=O)N)(C1=C(OCC2=CC=CC=C2)C=CC=C1)C3=CC(F)=CC=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Haranishi Y, et al. The antinociceptive effect of intrathecal administration of glycine transporter-2 inhibitor ALX1393 in a rat acute pain model. Anesth Analg. 2010 Feb 1;110(2):615-21.?
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