ZEN-3219( —— )

Catalog No. M33179 CAS No. 1952264-34-4

ZEN-3219 is a BET inhibitor, which has inhibitory effect on BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

ZEN-3219
Note

Research use only, not for human use.
Brief Description

ZEN-3219 is a BET inhibitor, which has inhibitory effect on BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2).
Description

ZEN-3219 is a BET inhibitor with IC50s of 0.48, 0.16 and 0.47 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively. ZEN-3219 can be used to form PROTACs to induce degradation of BRD4.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Epigenetic Reader Domain
Recptor

Epigenetic Reader Domain
Research Area

——
Indication

——

Chemical Information

CAS Number

1952264-34-4
Formula Weight

322.36
Molecular Formula

C19H18N2O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 25 mg/mL (77.55 mM; Ultrasonic )
SMILES

CC=1C(C2=CN(CC3=CC=C(C=C3)C4CO4)C(=O)C=C2)=C(C)ON1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Kharenko OA, et al. Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J Med Chem. 2018 Sep 27;61(18):8202-8211.?

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