TPN171
CAS No. 1229018-87-4
TPN171( —— )
Catalog No. M33154 CAS No. 1229018-87-4
TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary arterial hypertension (PAH).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 352 | In Stock |
|
| 5MG | 320 | In Stock |
|
| 10MG | 463 | In Stock |
|
| 25MG | 701 | In Stock |
|
| 50MG | 912 | In Stock |
|
| 100MG | 1256 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2520 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTPN171
-
NoteResearch use only, not for human use.
-
Brief DescriptionTPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary arterial hypertension (PAH).
-
DescriptionTPN171 is a potent, selective and oral bioavailable inhibitor of phosphodiesterase type 5 (PDE5) with an IC50 of 0.62 nM, being developed for the treatment of pulmonary arterial hypertension (PAH).
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayAngiogenesis
-
TargetPDE
-
RecptorPDE
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1229018-87-4
-
Formula Weight441.57
-
Molecular FormulaC24H35N5O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 25 mg/mL (56.62 mM; Ultrasonic (<60°C)
-
SMILESCCCOc1ccc(NC(=O)CN2CCN(C)CC2)cc1-c1nc(CC)c(CC)c(=O)[nH]1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Wang Z, et al. Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension. J Med Chem. 2019 May 23;62(10):4979-4990.?
molnova catalog
related products
-
Trequinsin hydrochlo...
Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PCE3 IC50=250 pM).
-
BRL 50481
BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15 12.1 62 and 490 μM for PDE7A PDE7B PDE4 and PDE3 respectively.
-
Piclamilast
Piclamilast is a PDE4 inhibitor.
Cart
sales@molnova.com