TPN171( —— )

Catalog No. M33154 CAS No. 1229018-87-4

TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary arterial hypertension (PAH).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	352	In Stock
5MG	320	In Stock
10MG	463	In Stock
25MG	701	In Stock
50MG	912	In Stock
100MG	1256	In Stock
200MG	Get Quote	In Stock
500MG	2520	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

TPN171
Note

Research use only, not for human use.
Brief Description

TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary arterial hypertension (PAH).
Description

TPN171 is a potent, selective and oral bioavailable inhibitor of phosphodiesterase type 5 (PDE5) with an IC50 of 0.62 nM, being developed for the treatment of pulmonary arterial hypertension (PAH).
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Angiogenesis
Target

PDE
Recptor

PDE
Research Area

——
Indication

——

Chemical Information

CAS Number

1229018-87-4
Formula Weight

441.57
Molecular Formula

C24H35N5O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 25 mg/mL (56.62 mM; Ultrasonic (<60°C)
SMILES

CCCOc1ccc(NC(=O)CN2CCN(C)CC2)cc1-c1nc(CC)c(CC)c(=O)[nH]1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Wang Z, et al. Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension. J Med Chem. 2019 May 23;62(10):4979-4990.?

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