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Home - Products - Proteasome/Ubiquitin - Endogenous Metabolite - Succinyl phosphonate

Succinyl phosphonate

CAS No. 26647-82-5

Succinyl phosphonate( —— )

Catalog No. M33130 CAS No. 26647-82-5

Succinyl phosphonate is a selective α-ketoglutarate dehydrogenase (α-KGDHC ) and OGDHC inhibitor that inhibits α-ketoglutarate oxidative decarboxylation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Succinyl phosphonate
  • Note
    Research use only, not for human use.
  • Brief Description
    Succinyl phosphonate is a selective α-ketoglutarate dehydrogenase (α-KGDHC ) and OGDHC inhibitor that inhibits α-ketoglutarate oxidative decarboxylation.
  • Description
    Succinyl phosphonate is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits(KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    Endogenous Metabolite | ROS
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    26647-82-5
  • Formula Weight
    182.07
  • Molecular Formula
    C4H7O6P
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(O)CCC(=O)P(=O)(O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Biryukov AI, et al. Succinyl phosphonate inhibits alpha-ketoglutarate oxidative decarboxylation, catalyzed by alpha-ketoglutarate dehydrogenase complexes from E. coli and pigeon breast muscle. FEBS Lett. 1996 Mar 11;382(1-2):167-70.?
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