Norbinaltorphimine dihydrochloride( —— )

Catalog No. M33039 CAS No. 113158-34-2

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Norbinaltorphimine dihydrochloride
Note

Research use only, not for human use.
Brief Description

Norbinaltorphimine dihydrochloride is a selective and potent κ opioid receptor antagonist that induces itch-associated responses in mice.
Description

Norbinaltorphimine dihydrochloride is a potent and selective κ opioid receptor antagonist.
In Vitro

Norbinaltorphimine reversibly antagonize the effects of κ agonists with pA2 values of 10.2-10.4. Norbinaltorphimine is much less potent as an antagonist at μ and δ receptors, pA2 values are 7.4-7.6 and 7.6-7.8, respectively.
In Vivo

Norbinaltorphimine has weak and inconsistent effects on THC-induced taste avoidance in adolescent rats in that Norbinaltorphimine both attenuates and strengthens taste avoidance dependent on dose and trial. Norbinaltorphimine has limited impact on the final one-bottle avoidance and no effects on the two-bottle preference test. Interestingly, Norbinaltorphimine has no effect on THC-induced taste avoidance in adult rats as well. Norbinaltorphimine pretreatment significantly attenuates stress-induced reinstatement of nicotine-CPP, but has no effect on nicotine-primed reinstatement.
Synonyms

——
Pathway

Endocrinology/Hormones
Target

Opioid Receptor
Recptor

Opioid Receptor
Research Area

——
Indication

——

CAS Number

113158-34-2
Formula Weight

734.71
Molecular Formula

C40H45Cl2N3O6
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (136.11 mM; Ultrasonic ) H2O : 33.33 mg/mL (45.36 mM; Ultrasonic)
SMILES

Cl.Cl.[H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)Cc1c4C[C@@]5(O)[C@@]6([H])Cc7ccc(O)c8O[C@@]([H])(c4[nH]c21)[C@]5(CCN6CC1CC1)c78)ccc3O
Chemical Name

——

1. Birch PJ, et al. Norbinaltorphimine: antagonist profile at kappa opioid receptors. Eur J Pharmacol. 1987 Dec 15;144(3):405-8.?

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