Methyllycaconitine citrate( —— )

Catalog No. M33022 CAS No. 351344-10-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Methyllycaconitine citrate
Note

Research use only, not for human use.
Brief Description

Methyllycaconitine citrate (MLA) is an α7 neuronal nicotinic acetylcholine receptor (α7nAChR) antagonist that crosses the blood-brain barrier.
Description

Methyllycaconitine citrate is a specific antagonist of α7 neuronal nicotinic acetylcholine receptor (α7nAChR) with blood-brain barrier permeability.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

AChR
Recptor

AChR
Research Area

——
Indication

——

CAS Number

351344-10-0
Formula Weight

874.92
Molecular Formula

C43H58N2O17
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (142.87 mM; Ultrasonic ) H2O : 2.18 mg/mL (2.49 mM)
SMILES

OC(=O)CC(O)(CC(O)=O)C(O)=O.[H][C@]12C[C@]3([H])[C@]([H])([C@H]1OC)[C@](O)(C[C@@H]2OC)C1(O)[C@@H](OC)[C@@]2([H])C33C1N(CC)C[C@]2(COC(=O)c1ccccc1N1C(=O)C[C@H](C)C1=O)CC[C@@H]3OC
Chemical Name

——

1. Zheng X, et al. Methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cells. PLoS One. 2014 Oct 31;9(10):e111536.?

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