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Terodiline

CAS No. 15793-40-5

Terodiline( —— )

Catalog No. M35434 CAS No. 15793-40-5

Terodiline is a seconal amine with anticholinergic and calcium antagonistic properties that blocks the hERG current (IC50: 375 nM).Terodiline is cardiotoxic and has been used in the study of disorders caused by urethral muscle instability.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Terodiline
  • Note
    Research use only, not for human use.
  • Brief Description
    Terodiline is a seconal amine with anticholinergic and calcium antagonistic properties that blocks the hERG current (IC50: 375 nM).Terodiline is cardiotoxic and has been used in the study of disorders caused by urethral muscle instability.
  • Description
    Terodiline, an antispasmodic agent, blocks hERG current with the IC50 of 375 nM. Terodiline has both anticholinergic and calcium antagonist properties, and effectively reduces abnormal bladder contractions caused by detrusor instability. Terodiline can be used for the research of urinary incontinence.
  • In Vitro
    ——
  • In Vivo
    Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID50= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED50=59 mg/kg).Animal Model:Fmale or male Hartley guinea pigs (200-600 g)Dosage:80 mg/kg Administration:Administered S.C. Result:Yielded an ID50 of 24±6 mg/kg. Higher doses were Iethal.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    AChR
  • Recptor
    AChR | HER | Calcium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    15793-40-5
  • Formula Weight
    281.44
  • Molecular Formula
    C20H27N
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C=1C=CC(=CC1)C(C=2C=CC=CC2)CC(NC(C)(C)C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ruth L Martin, et al. In vitro preclinical cardiac assessment of tolterodine and terodiline: multiple factors predict the clinical experience. J Cardiovasc Pharmacol.?2006 Nov;48(5):199-206.?
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