MC3482 B( —— )

Catalog No. M33011 CAS No. 2922280-86-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MC3482 B
Note

Research use only, not for human use.
Brief Description

MC3482 is a specific inhibitor of sirtuin5 (SIRT5).
Description

MC3482 is a specific sirtuin5 (SIRT5) inhibitor.
In Vitro

MC3482 inhibits sirtuin5. 50 μM MC3482 inhibits SIRT5 desuccinylating activity without affecting SIRT5 intracellular expression levels. Autophagy and mitophagy increase in SIRT5-silenced cells and in WT cells treated with MC3482 and decrease in SIRT5-overexpressing cells.
In Vivo

——
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Sirtuin
Recptor

Sirtuin
Research Area

——
Indication

——

CAS Number

2922280-86-0
Formula Weight

618.68
Molecular Formula

C33H38N4O8
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : ≥ 130 mg/mL (210.12 mM)
SMILES

[C@H](C(NC1=CC=CC=C1)=O)(NC(OCC2=CC=CC=C2)=O)CCCCNC(CC[C@H](NC(OCC3=CC=CC=C3)=O)C(O)=O)=O
Chemical Name

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1. Polletta L, et al. SIRT5 regulation of ammonia-induced autophagy and mitophagy. Autophagy. 2015;11(2):253-70.?

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