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M2698
CAS No. 1379545-95-5
M2698( —— )
Catalog No. M33004 CAS No. 1379545-95-5
M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 119 | In Stock |
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| 5MG | 102 | In Stock |
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| 10MG | 164 | In Stock |
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| 25MG | 330 | In Stock |
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| 50MG | 465 | In Stock |
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| 100MG | 642 | In Stock |
|
| 200MG | 864 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameM2698
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NoteResearch use only, not for human use.
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Brief DescriptionM2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity.
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DescriptionM2698 (MSC2363318A) is an orally active, ATP competitive, selective p70S6K and Akt dual-inhibitor with IC50s of 1 nM for p70S6K, Akt1 and Akt3. M2698 can cross the blood-brain barrier and has anti-cancer activity.
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In VitroCell Proliferation AssayCell Line:Breast tumors cell lines Concentration:0.3 nM to 50 M Incubation Time:72 hours Result:Inhibited proliferation in a dose-dependent manner.Western Blot Analysis Cell Line:HCC1419 and MDA-MB-453 cells Concentration: 0.3, 1 μM Incubation Time:24 hours Result:Inhibited p70S6K activity and induced feedback loop phosphorylation on Akt and suppressed Akt activity in breast cancer cell lines.
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In VivoAnimal Model:Female nude mice bearing MDA-MB-468 tumorsDosage:10, 20 and 30 mg/kg Administration:PO; daily; for 28 days Result:Resulted in dose-dependent inhibition of tumor growth and resulted in tumor regression with the highest dose of 30 mg/kg.Animal Model:Female SCID Beige mice with MDA-MB-453 xenografted Dosage:20 mg/kg (Pharmacokinetic Analysis) Administration:Daily; for 4 days Result:Had a tumor:plasma exposure ratio of 12:1 over 24 hours.
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Synonyms——
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorAkt | mTOR
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Research Area——
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Indication——
Chemical Information
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CAS Number1379545-95-5
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Formula Weight449.86
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Molecular FormulaC21H19ClF3N5O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (277.86 mM; Ultrasonic )
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SMILESN([C@H](CN1CCC1)C2=CC(C(F)(F)F)=C(Cl)C=C2)C=3C4=C(C(C(N)=O)=CC=C4)N=CN3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Machl A, et al. M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier. Am J Cancer Res. 2016 Mar 15;6(4):806-18.?
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