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GSK205
CAS No. 1263068-83-2
GSK205( —— )
Catalog No. M32950 CAS No. 1263068-83-2
GSK205 is a selective TRPV4 antagonist that blocks Ca(2+) signaling and may be used to reduce inflammation and pain.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 157 | In Stock |
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| 5MG | 148 | In Stock |
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| 10MG | 235 | In Stock |
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| 25MG | 519 | In Stock |
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| 50MG | 830 | In Stock |
|
| 100MG | 1330 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSK205
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NoteResearch use only, not for human use.
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Brief DescriptionGSK205 is a selective TRPV4 antagonist that blocks Ca(2+) signaling and may be used to reduce inflammation and pain.
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DescriptionGSK205 is a potent, selective TRPV4 antagonist with an IC50 of 4.19 μM for inhibiting TRPV4-mediated Ca2+ influx.
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In VitroRT-PCR Cell Line:T3-F442A adipocytes Concentration:5 μM Incubation Time:4 days Result:Resulted in increased expression of thermogenic genes and is also accompanied by a decrease in the proinflammatory gene program.
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In VivoAnimal Model:Male C57BL/6J mice with high-fat dietDosage:10 mg/kg Administration:Intraperitoneal injection; twice daily; for 7 days Result:Caused a reduced expression of the proinflammatory chemokines, macrophage marker and Tnfa in the EPI fat. Significantly improved glucose tolerance in diet-induced obese (DIO) mice.
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Synonyms——
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorCalcium Channel | TRP/TRPV Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number1263068-83-2
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Formula Weight481.45
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Molecular FormulaC24H25BrN4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (519.26 mM; Ultrasonic )
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SMILESBr.CN(CCc1ccc(Nc2ncc(s2)-c2cccnc2)cc1)Cc1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ye L, et al. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012 Sep 28;151(1):96-110.?
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