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Giredestrant tartrate
CAS No. 2407529-33-1
Giredestrant tartrate( —— )
Catalog No. M32918 CAS No. 2407529-33-1
Giredestrant tartrate (Estrogen receptor antagonist 1) is a novel, orally active, selective and effective non-steroidal estrogen receptor antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 255 | In Stock |
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| 10MG | 375 | In Stock |
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| 25MG | 562 | In Stock |
|
| 50MG | 770 | In Stock |
|
| 100MG | 1051 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGiredestrant tartrate
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NoteResearch use only, not for human use.
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Brief DescriptionGiredestrant tartrate (Estrogen receptor antagonist 1) is a novel, orally active, selective and effective non-steroidal estrogen receptor antagonist.
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DescriptionGiredestrant tartrate (GDC-9545 tartrate), a non-steroidal ER ligand, is an orally active and selective estrogen receptor (ER) antagonist. Giredestrant tartrate potently competes with estradiol for binding and induces a conformational change within the ER ligand binding domain. Anti-tumor activity.
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In VitroGiredestrant (GDC-9545) tartrate consistently induces ER turnover and drives deep transcriptional suppression of ER, resulting in robust in vitro anti-proliferative activity.
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In VivoGiredestrant (GDC-9545) tartrate is an ER antagonist that combines desirable mechanistic and pre-clinical DMPK attributes. The highly potent in vivo efficacy of Giredestrant likely arises due to the particular combination of high binding potency, full suppression of ER signaling, and an improved DMPK profile.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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RecptorEstrogen Receptor/ERR
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Research Area——
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Indication——
Chemical Information
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CAS Number2407529-33-1
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Formula Weight672.64
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Molecular FormulaC31H37F5N4O7
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Purity>98% (HPLC)
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Solubility——
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SMILES[C@@H]([C@H](C(O)=O)O)(C(O)=O)O.C(C(CO)(F)F)N1[C@@H](C2=C(C=3C(N2)=CC=CC3)C[C@H]1C)C4=C(F)C=C(NC5CN(CCCF)C5)C=C4F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. C Metcalfe, et al. Abstract P5-04-07: GDC-9545: A novel ER antagonist and clinical candidate that combines desirable mechanistic and pre-clinical DMPK attributes.
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