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G15
CAS No. 1161002-05-6
G15( —— )
Catalog No. M20708 CAS No. 1161002-05-6
G15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 79 | In Stock |
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| 5MG | 71 | In Stock |
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| 10MG | 119 | In Stock |
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| 25MG | 217 | In Stock |
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| 50MG | 362 | In Stock |
|
| 100MG | 544 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameG15
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NoteResearch use only, not for human use.
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Brief DescriptionG15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM).
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DescriptionG15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM).
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In VitroCell Proliferation Assay Cell Line:A549, H1793 cell lines Concentration:0.1, 1, 10 μM (combination with 10 nM E2)Incubation Time:2 days Result:Inhibited GPER-mediated proliferation stimulated by E2.Western Blot Analysis Cell Line:A549, H1793 cell lines Concentration:1 μM (combination with 10 nM E2 and 10 nM G1)Incubation Time:48 hours Result:Inhibited the response of GPER stimulated by E2 and G1.
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In VivoAnimal Model:Four-week-old female Kunming mice (Urethane-induced adenocarcinoma) Dosage:1.46 mg/kg (combination with E2, 0.09 mg/kg and fulvestrant (Ful), 2.4 mg/kg) Administration:Subcutaneous injection; twice a week for 14 weeks Result:The number of tumor nodules decreased in the E2+Ful+G15 group.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetEstrogen Receptor/ERR
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RecptorGPER
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Research Area——
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Indication——
Chemical Information
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CAS Number1161002-05-6
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Formula Weight370.24
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Molecular FormulaC19H16BrNO2
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Purity>98% (HPLC)
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SolubilityDMSO:41.67 mg/mL (112.55 mM)
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SMILES[H][C@]12CC=C[C@@]1([H])c1ccccc1N[C@H]2c1cc2OCOc2cc1Br
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Chemical Name(3aS4R9bR)-4-(6-bromo-13-benzodioxol-5-yl)-3a459b-tetrahydro-3H-cyclopenta[c]quinoline
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Nayak T K Bologa C G Leitao A et al. In vivo effects of a GPR30 antagonist[J]. Nature Chemical Biology 2009 5(6):421-427.
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