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BAN ORL 24 dihydrochloride
CAS No. 1401463-54-4
BAN ORL 24 dihydrochloride( —— )
Catalog No. M32796 CAS No. 1401463-54-4
BAN ORL 24 is a highly potent nociceptin/orphan FQ (N/OFQ) receptor (NOP) antagonist that can be used to study neurological diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameBAN ORL 24 dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionBAN ORL 24 is a highly potent nociceptin/orphan FQ (N/OFQ) receptor (NOP) antagonist that can be used to study neurological diseases.
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DescriptionBAN ORL 24 is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) antagonist. BAN ORL 24 has antagonistic effect for nociceptin (NOP) receptor with KI value of 0.24 nM in CHO cell. BAN ORL 24 can be used for the research of cancer and analgesic.
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In VitroBAN ORL 24 has antagonist for NOR and MOR (opioid receptor subtype) with IC50 values of 50 μM and 0.224 μM, respectively.
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In VivoBAN ORL 24 (10 mg/kg; i.v.) attenuates the duration of BPRIM97 thermal antinociception.Animal Model:C57BL/6 mice Dosage:10 mg/kg Administration:10 mg/kg; i.v.Result:Caused inhibition of BPRIM97-induced antinociception at 90-min post injection.Did not attenuate BPR1M97-induced antinociception in the tail-clip test after 30 min.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetOpioid Receptor
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RecptorOpioid Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1401463-54-4
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Formula Weight506.51
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Molecular FormulaC27H37Cl2N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 200 mg/mL (394.86 mM; Ultrasonic ) H2O : 100 mg/mL (197.43 mM; Ultrasonic)
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SMILESO=C([C@@H]1N(CCC1)CC2=CC=CC=C2)NCCCN3CCC4(CC3)C5=CC=CC=C5CO4.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fischetti et al (2009) Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist compound 24. Eur.J.Pharmacol. 614 50.?
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