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ATX inhibitor 5
CAS No. 2402772-45-4
ATX inhibitor 5( —— )
Catalog No. M32793 CAS No. 2402772-45-4
ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50: 15.3 nM) that reduces CCl4-induced hepatic fibrosis and exhibits anti-hepatic fibrosis effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 98 | In Stock |
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| 5MG | 95 | In Stock |
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| 10MG | 153 | In Stock |
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| 25MG | 259 | In Stock |
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| 50MG | 349 | In Stock |
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| 100MG | 476 | In Stock |
|
| 200MG | 642 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameATX inhibitor 5
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NoteResearch use only, not for human use.
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Brief DescriptionATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50: 15.3 nM) that reduces CCl4-induced hepatic fibrosis and exhibits anti-hepatic fibrosis effects.
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DescriptionATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC50 of 15.3 nM. ATX inhibitor 5 shows anti-hepatofibrosis effects and reduces CCl4-induced hepatic fibrosis level prominently.
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In VitroATX inhibitor 5 (compound 10g) (IC50s=1.21 and 0.78 μM) displays activities against cardiac fibroblasts (CFs) and hepatic stellate cell (HSC).ATX inhibitor 5 at 10 μM successfully suppresses collagen content induced by TGF-β.Cell Proliferation Assay Cell Line:CFs and t-HSC/Cl-6 cells Concentration:0.0001, 0.01, 1, 100, 10000 μM Incubation Time:48 hours Result:Displayed activities against CFs and t-HSC/Cl-6 cells with IC50s of 1.21 and 0.78 μM, respectively.
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In VivoATX inhibitor 5 (20-40 mg/kg; p.o.; once daily for two weeks) reduces CCl4-induced hepatic fibrosis level prominently.Animal Model:Male Konmin mice (8-week old, 22-25 g)Dosage:20, 40 mg/kg Administration:Orally; once daily for two weeks Result:Prominently reduced CCl4-induced hepatic fibrosis level.
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Synonyms——
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE
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Research Area——
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Indication——
Chemical Information
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CAS Number2402772-45-4
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Formula Weight474.87
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Molecular FormulaC22H18ClF3N6O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (526.46 mM; Ultrasonic )
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SMILESFC(F)(F)c1cccc(Nc2ncnc3CCN(Cc23)C(=O)N\N=C\c2ccc(Cl)cc2)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jiang N, et al.Optimization and evaluation of novel tetrahydropyrido[4,3-d]pyrimidine derivatives as ATX inhibitors for cardiac and hepatic fibrosis.Eur J Med Chem.?2020 Feb 1;187:111904.?
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