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Tuvusertib
CAS No. 1613200-51-3
Tuvusertib( —— )
Catalog No. M32792 CAS No. 1613200-51-3
Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 μΜ) with selective and potentially antitumor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 103 | Get Quote |
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| 5MG | 157 | Get Quote |
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| 10MG | 244 | Get Quote |
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| 25MG | 456 | Get Quote |
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| 50MG | 637 | Get Quote |
|
| 100MG | 881 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTuvusertib
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NoteResearch use only, not for human use.
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Brief DescriptionTuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 μΜ) with selective and potentially antitumor activity.
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DescriptionTuvusertib (M1774; ATR inhibitor 1) is a selective and orally active ATR inhibitor extracted from patent WO2015187451A1, compound I-l, with a Ki value below 1 μΜ.
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In VitroWestern Blot Analysis Cell Line:U266 and OPM2 cells Concentration:0-2 μM Incubation Time:24 h Result:Increased level of γH2A.X, cleavage of caspase-3, and cleavage of PARP.
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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TargetChk
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RecptorChk | ATM/ATR | Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number1613200-51-3
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Formula Weight370.32
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Molecular FormulaC16H12F2N8O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (13.50 mM; Ultrasonic )
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SMILESCn1cncc1-c1c(F)cncc1NC(=O)c1c(N)nn2cc(F)cnc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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SAR-020106
SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3 nmol/L on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55 nmol/L in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion.
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GDC0575 monohydrochl...
GDC-0575 is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2?nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
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XL-844
A potent, specific, orally available, ATP?competitive inhibitor of Chk1 and Chk2 with Ki of 2.2 nM and 0.07 nM, respectively.
