Cart
sales@molnova.com
PV-1019
CAS No. ——
PV-1019( NSC-744039 | NSC744039 | PV1019 )
Catalog No. M16921 CAS No. ——
A potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NamePV-1019
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM.
-
DescriptionA potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM; displays much reduced or no activity against a panel of 52 other cellular kinases, including Chk1; inhibits Chk2-mediated phosphorylation of Cdc25C (IC50=260 nM), and nd HDMX degradation in response to DNA damage; protects normal mouse thymocytes against ionizing radiation-induced apoptosis.
-
In Vitro——
-
In Vivo——
-
SynonymsNSC-744039 | NSC744039 | PV1019
-
PathwayAngiogenesis
-
TargetChk
-
RecptorChk
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number——
-
Formula Weight379.38
-
Molecular FormulaC18H17N7O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
CCT-245737
A highly potent, selective, ATP-competitive inhibitor of Chk1 with IC50 of 1.3 nM; weak inhibition on Chk2 (IC50=2440 nM).
-
CCT241533 hydrochlor...
A potent and selective ATP-competitive inhibitor of CHK2 K5777:N5777with IC50 of 3 nM; shows good selectivity for CHK2 against CHK1 (IC50=180 nM) .
-
SAR-020106
SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3 nmol/L on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55 nmol/L in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion.
