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Home - Products - Chromatin/Epigenetic - COX - Apyramide

Apyramide

CAS No. 68483-33-0

Apyramide( —— )

Catalog No. M32784 CAS No. 68483-33-0

Apyramide is an anti-inflammatory agent (NSAID) that acts as a prodrug of indomethacin, a potent, blood-brain permeable, and nonselective inhibitor of COX1 and COX2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 55 In Stock
5MG 39 In Stock
10MG 68 In Stock
25MG 119 In Stock
50MG 170 In Stock
100MG 231 In Stock
200MG 316 In Stock
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Biological Information

  • Product Name
    Apyramide
  • Note
    Research use only, not for human use.
  • Brief Description
    Apyramide is an anti-inflammatory agent (NSAID) that acts as a prodrug of indomethacin, a potent, blood-brain permeable, and nonselective inhibitor of COX1 and COX2.
  • Description
    Apyramide is an anti-inflammatory agent (NSAID) and behaves as a proagent of indomethacin (HY-14397). Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2.
  • In Vitro
    ——
  • In Vivo
    Apyramide is far less toxic than indomethacin in rats and mice by the oral or the i.p. route. It exhibits anti-inflammatory activity on carrageenin-induced paw oedema, cotton pellet granuloma and adjuvant arthritis, as well as analgesic and antipyretic activities.
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    COX
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    68483-33-0
  • Formula Weight
    490.93
  • Molecular Formula
    C27H23ClN2O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(=O)(N1C=2C(C(CC(OC3=CC=C(NC(C)=O)C=C3)=O)=C1C)=CC(OC)=CC2)C4=CC=C(Cl)C=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sauvaire D, et al. Pharmacological activity and toxicity of apyramide: comparison with non-steroidal anti-inflammatory agents. Drugs Exp Clin Res. 1987;13(5):247-52.?
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