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COX-2-IN-2
CAS No. 134729-13-8
COX-2-IN-2( —— )
Catalog No. M32736 CAS No. 134729-13-8
COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 424 | In Stock |
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| 5MG | 416 | In Stock |
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| 10MG | 668 | In Stock |
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| 25MG | 1330 | In Stock |
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| 50MG | 2074 | In Stock |
|
| 100MG | 2753 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCOX-2-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionCOX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM.
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DescriptionCOX-2-IN-2 is a selective and inducible COX2 inhibitor with an IC50 of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.
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In VitroCOX-2-IN-2 shows no COX-1 inhibition even at 100μM.
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In VivoCOX-2-IN-2 has oral ED50 values of 0.030 and 0.47mg/kg on adjuvant-induced arthritis and collagen-induced arthritis, respectively, and an ED30 value of 7.4mg/kg in the yeast-induced hyperalgesia (Randall-Selitto) assay. COX-2-IN-2 shows good analgesic activity and no ulcerogenicity.
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX
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Research Area——
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Indication——
Chemical Information
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CAS Number134729-13-8
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Formula Weight341.36
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Molecular FormulaC17H12FN3O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESC(#N)C=1C=C(N(N1)C2=CC=C(F)C=C2)C3=CC=C(S(C)(=O)=O)C=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tsuji K, et al. Studies on anti-inflammatory agents. IV. Synthesis and pharmacological properties of 1,5-diarylpyrazoles and related derivatives. Chem Pharm Bull (1997), 45(6), 987-995.
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