4-Hydroxywogonin

Research use only, not for human use.

4'-Hydroxywogonin has positive effect on inhabiting those human tumor lines in vitro, with IC50 value is 8.3-38.4ug/mL .

4'-Hydroxywogonin has positive effect on inhabiting those human tumor lines in vitro, with IC50 value is 8.3-38.4ug/mL .

4′-Hydroxywogonin (8-Methoxyapigenin; 0.5-15 μM; 0-24 h) has low cytotoxicity and inhibits NO and PGE2 production in LPS-stimulated RAW 264.7 macrophages by suppression of iNOS and COX-2 expression.4′-Hydroxywogonin (0.5-15 μM; 1 and 12 h) suppresses LPS-induced expression of pro-inflammatory cytokines in RAW 264.7 macrophages and suppresses LPS-induced activation of NF-κB.4′-Hydroxywogonin (0.5-15 μM; 1 h) suppresses LPS-induced degradation of IκB-α and activation of IKK and TAK and suppresses the phosphorylation of MAPK and AKTin in RAW 264.7 macrophages.4′-Hydroxywogonin (0.5-15 μM; 24 h) inhibits ROS production in LPS-stimulated RAW 264.7 macrophages.4′-Hydroxywogonin (0-10 μg/mL; 24 h) reduces the viability of SW620?cells in a concentration- and time-dependent manner and decreases the mRNA and protein expression of vascular endothelial growth factor-A (VEGF-A), the predominant pro-angiogenic cytokine in tumor angiogenesis.4′-Hydroxywogonin (24 h; SUP-B15 and Jurkat cells) induces apoptosis and decreases the expression of C-MYC, BCL-2 and cleaved caspase 3.Cell Viability Assay Cell Line:RAW 264.7 macrophages Concentration:0.5, 5 and 15 μM Incubation Time:24 hours Result:Had low cytotoxicity in RAW 264.7 macrophages.Western Blot Analysis Cell Line:RAW 264.7 macrophages Concentration:0.5, 5 and 15 μM Incubation Time:1 hours Result:Attenuated the increase of iNOS and COX-2 mRNA expression induced by LPS in RAW 264.7 cells.Western Blot Analysis Cell Line:RAW 264.7macrophages Concentration:0.5, 5 and 15 μM Incubation Time:1 and 12 hours Result:Reduced TNF-α, IL-6 and IL-1β mRNA expression in a dose-dependent manner.Inhibited LPS-induced p65 phosphorylation and nuclear translocation.Western Blot Analysis Cell Line:RAW 264.7 macrophages Concentration:0.5, 5 and 15 μM Incubation Time:1 hours Result:Attenuated LPS induced IκB-α degradation.Attenuated the phosphorylation of ERK1/2 and p38 in a dose-dependent manner.Reduced the intensity of the TAK1/TAB1 band.Western Blot Analysis Cell Line:SW620 cells Concentration:0.1, 1, and 10 μg/mL Incubation Time:24 hours Result:Downregulated VEGF-Aexpression in colorectal cancer cells and suppressed angiogenesis.

4′-Hydroxywogonin (10 and 20 mg/kg; i.p.; male C57BL/6 mice) alleviates LPS-induced acute lung injury (ALI) in a mouse model. Animal Model:Male C57BL/6 mice (6-8 weeks old; 20 g) with acute lung injury model Dosage:10 and 20 mg/kg Administration:Intraperitoneal injection, 12 and 1 h before LPS treatment Result:Had potential protective effects against inflammation in LPS induced ALI mice.Attenuated the degree of leukocyte infiltration.

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Others

Other Targets

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57096-02-3

300.3

C16H12O6

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years