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CYN 154806
CAS No. 183658-72-2
CYN 154806( —— )
Catalog No. M30575 CAS No. 183658-72-2
CYN 154806 is a potent and selective somatostatin sst2 receptor antagonist, The pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameCYN 154806
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NoteResearch use only, not for human use.
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Brief DescriptionCYN 154806 is a potent and selective somatostatin sst2 receptor antagonist, The pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.
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DescriptionCYN 154806 is a potent and selective somatostatin sst2 receptor antagonist, The pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively.
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In VitroCYN 154806 inhibits SRIF-induced increases in extracellular acidification (EAR) in CHO-K1 cells expressing human sst2 receptors (pKB 7.92). CYN 154806 also blocks SRIF-induced increases [35S]-GTPγS binding in CHO-K1 cell membranes expressing human sst2 receptors as well as rat sst2(a) and rat sst2(b) receptors (pKB 7.81, 7.68 and 7.96, respectively).
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In VivoCYN 154806 (0.1 mg/kg; i.p.; 20 minbefore the administration of carbachol (CCh) (30 μg/kg) in M4 KO mice) dose-dependently and significantly reverses the decreases acid response to CCh in M4 but not M3 KO mice.
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Synonyms——
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PathwayGPCR/G Protein
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TargetSomatostatin Receptor
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RecptorSomatostatin Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number183658-72-2
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Formula Weight1197.34
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Molecular FormulaC56H68N12O14S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 12.5 mg/mL (10.44 mM)
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SMILES——
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Chemical NameSequence:Ac-FCYWKTCY-NH2 (Disulfide bridge: Cys2-Cys7)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
Bass RT, et al. Identification and characterization of novel somatostatin antagonists. Mol Pharmacol. 1996 Oct;50(4):709-15.
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