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Galanin (1-30), human
CAS No. 119418-04-1
Galanin (1-30), human( —— )
Catalog No. M30430 CAS No. 119418-04-1
Galanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors, with Kis of both 1 nM. Endogenous peptide with multiple endocrine, metabolic and behavioral effects. Has been shown to have an action on intestinal smooth muscle, insulin and somatostatin release, and synaptic neurotransmission.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NameGalanin (1-30), human
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NoteResearch use only, not for human use.
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Brief DescriptionGalanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors, with Kis of both 1 nM. Endogenous peptide with multiple endocrine, metabolic and behavioral effects. Has been shown to have an action on intestinal smooth muscle, insulin and somatostatin release, and synaptic neurotransmission.
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DescriptionGalanin (1-30), human is a 30-amino acid neuropeptide, and acts as an agonist of GalR1 and GalR2 receptors, with Kis of both 1 nM. Endogenous peptide with multiple endocrine, metabolic and behavioral effects. Has been shown to have an action on intestinal smooth muscle, insulin and somatostatin release, and synaptic neurotransmission.(In Vitro):Galanin (1-30), human (Gal1-30) is an agonist of GalR1 and GalR2 receptors, with Kis of both 1 nM. Galanin (1-30), human displaces 125I-labeled rat galanin with a Kd of 0.5 nM. Galanin (1-30), human (hGal) causes contractions of isolated longitudinal rat fundus strips, with an ED50 of 13.8 ± 1.6 nM.
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In VitroGalanin (1-30), human (Gal1-30) is an agonist of GalR1 and GalR2 receptors, with Kis of both 1 nM. Galanin (1-30), human displaces 125I-labeled rat galanin with a Kd of 0.5 nM. Galanin (1-30), human (hGal) causes contractions of isolated longitudinal rat fundus strips, with an ED50 of 13.8 ± 1.6 nM.
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetNeuropeptide Y Receptor
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RecptorKd: 1 nM (GalR1 receptor), 1 nM (GalR2 receptor)
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Research Area——
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Indication——
Chemical Information
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CAS Number119418-04-1
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Formula Weight3157.46
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Molecular FormulaC139H210N42O43
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 1 mg/mL (0.32 mM)
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SMILES——
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Chemical NameSequence:Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr-Ser
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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GW438014A
GW438014A is a potent, selective antagonist of the NPY-Y5 receptor, effectively inhibiting food consumption and curbing body weight gain in obese rodents.
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M 1145
Potent and selective galanin receptor 2 (GAL2) agonist (EC50 = 38 nM, Ki values are 6.55, 497 and 587 nM at GAL2, GAL3 and GAL1 respectively). Has an additive effect on the signal transduction of galanin.
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Neuropeptide Y (22-3...
Neuropeptide Y (22-36), a 15 amino acid peptide, is a fragment of Neuropeptide Y.Neuropeptide Y (NPY) is a 36 amino-acid neuropeptide that is involved in various physiological and homeostatic processes in both the central and peripheral nervous systems. NPY has been identified as the most abundant peptide present in the mammalian central nervous system, which consists of the brain and spinal cord. It is secreted alongside other neurotransmitters such as GABA and glutamate.
