Urotensin II (114-124), human TFA( —— )

Catalog No. M30114 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Urotensin II (114-124), human TFA
Note

Research use only, not for human use.
Brief Description

Urotensin II (114-124), human TFA, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
Description

Urotensin II (114-124), human TFA, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.(In Vitro):Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC50=0:62±0.17 nM, n=6).(In Vivo):Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction.
In Vitro

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In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

GPR14
Research Area

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Indication

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CAS Number

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Formula Weight

1502.59
Molecular Formula

C66H86F3N13O20S2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

Sequence:Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val (Disulfide bridge: Cys5-Cys7)

Ames RS, et al. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature. 1999 Sep 16;401(6750):282-6.

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