Atrial Natriuretic Peptide (ANP) (1-28), rat( Atrial natriuretic factor (1-28) (rat) )

Catalog No. M29920 CAS No. 88898-17-3

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MSDS

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Product Name

Atrial Natriuretic Peptide (ANP) (1-28), rat
Note

Research use only, not for human use.
Brief Description

Atrial Natriuretic Peptide (1-28), rat is the major circulating form of ANP in rats.
Description

Atrial Natriuretic Peptide (1-28), rat is the major circulating form of ANP in rats.(In Vitro):Rat ANP (1-28) and rat BNP-45, which are the respective major circulating forms of ANP and BNP in rats, potently inhibited Ang II-stimulated endothelin-1 secretion in a concentration-dependent manner. Rat ANP (5-25) is less effective that Rat ANP(1-28) with respect to inhibiting immunoreactive (ir)-endothelin-1 secretion and increasing cellular cyclic GMP. Rat ANP (1-28) inhibits the secretion of ir-endothelin-1 in a concentration-dependent manner between 0.01 and 1 μM.
In Vitro

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In Vivo

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Synonyms

Atrial natriuretic factor (1-28) (rat)
Pathway

GPCR/G Protein
Target

Endothelin Receptor
Recptor

Endothelin-1
Research Area

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Indication

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CAS Number

88898-17-3
Formula Weight

3062.41
Molecular Formula

C128H205N45O39S2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

Sequence:Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys7-Cys23)

Kohno M, et al. Angiotensin II stimulates endothelin-1 secretion in cultured rat mesangial cells. Kidney Int. 1992 Oct;42(4):860-6.

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