PAR-4 Agonist Peptide, amide

Research use only, not for human use.

PAR-4 agonist peptide stimulates thromboxane production by human platelets with the maximal response to this agonist being approximately half of that observed after maximal thrombin stimulation.

PAR-4 agonist peptide stimulates thromboxane production by human platelets with the maximal response to this agonist being approximately half of that observed after maximal thrombin stimulation.(In Vivo):Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05) .

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Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05) .

PAR-4-AP; AY-NH2

GPCR/G Protein

PAR

PAR-4

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352017-71-1

680.79

C34H48N8O7

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (146.89 mM)

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Sequence:Ala-Tyr-Pro-Gly-Lys-Phe-NH2

(-20℃)

With Ice Pack

≥ 2 years