tcY-NH2

Research use only, not for human use.

Selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.

Selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.

tcY-NH2 (0-500 μM) inhibits AYPGKF-NH2 (10 μM)-induced platelet (obtained from male albino Sprague–Dawley rats) aggregation, with an IC50 value of 95 μM.tcY-NH2 potently activates aorta relaxation (RA) and gastric (LM) contraction, with IC50 values of 64 μM (RA) and 1 μM (LM).tcY-NH2 (Tc-YPGKF-NH2, 400 μM, 5 min) prevents endostatin release and platelet aggregation induced by thrombin or by AY-NH2.tcY-NH2 (5 μM, 15 min) decreases infarct size (IS) by 51%, and increases recovery of ventricular function by 26% in an isolated heart model.

tcY-NH2 (tail vein injection, 0.6 mg/kg for a single dose) alleviates liver injury in Brain death (BD) rat model, indicated by lower serum ALT/AST levels and better histomorphology.tcY-NH2 (intraperitoneal injection, 0.6 mg/kg for a single dose) increases posttraumatic activation of CD4+ Tregs within the draining lymph nodes in burn injury mice model .tcY-NH2 (intrapleural injection, 40 ng/kg for a single dose) inhibits neutrophil recruitment in experimental inflammation in mice. Animal Model:Brain death (BD) rat model Dosage:0.6 mg/kg for a single doseAdministration:Tail vein injection for a single dose Result:Reduced blood platelet activation and hepatic platelet accumulation.Attenuated the inflammatory response and apoptosis in the livers.Inhibited the activation of NF-κB and MAPK pathways induced by Brain death (BD).Animal Model:Burn injury model of C57BL/6 N mice Dosage:0.6 mg/kg for a single dose Administration:Intraperitoneal injection Result:Increased expression and phosphorylation of PKC-θ in the presence of platelets, without affecting early posttraumatic hemostasis.Animal Model:BALB/c mice Dosage:40 ng/kg for a single dose Administration:Intrapleural injection Result:Abolished the number of rolling and adhering neutrophils on the vessel wall.Inhibited CXCL8- and Cg-induced neutrophil migration into the pleural cavity of mice.

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GPCR/G Protein

PAR

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327177-34-4

739.87

C40H49N7O7

>98% (HPLC)

water:1 mg/mL

NCCCC[C@H](NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)\C=C\C1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

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(-20℃)

With Ice Pack

≥ 2 years