Cart
sales@molnova.com
Home - Products - GPCR/G Protein - CRF Receptor - Urocortin, rat

Urocortin, rat

CAS No. 171543-83-2

Urocortin, rat( Urocortin (Rattus norvegicus); Rat urocortin )

Catalog No. M29719 CAS No. 171543-83-2

Endogenous CRF agonist. Ki values are 13, 1.5 and 0.97 nM for hCRF1, rCRF2α and mCRF2β respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 737 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Urocortin, rat
  • Note
    Research use only, not for human use.
  • Brief Description
    Endogenous CRF agonist. Ki values are 13, 1.5 and 0.97 nM for hCRF1, rCRF2α and mCRF2β respectively.
  • Description
    Endogenous CRF agonist. Ki values are 13, 1.5 and 0.97 nM for hCRF1, rCRF2α and mCRF2β respectively. (In Vitro):Urocortin, rat is a selective agonist of CRF receptor, with Kis of 0.32, 2.2, and 0.62 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively.(In Vivo):Urocortin (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such a effect also observed in mice after 1 μg of Urocortin i.c.v. administration. Urocortin has the potential of inducing anxiogenic behavior.
  • In Vitro
    Urocortin, rat induces cyclic AMP (cAMP) generation with EC50 of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF1, rat CRF2α and mouse CRF2β, respectively in stably transfected Chinese hamster ovary cells.
  • In Vivo
    Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat i.c.v. administration. Urocortin, rat has the potential of inducing anxiogenic behavior.
  • Synonyms
    Urocortin (Rattus norvegicus); Rat urocortin
  • Pathway
    GPCR/G Protein
  • Target
    CRF Receptor
  • Recptor
    Ki: 0.32 nM (hCRF1), 2.2 nM (rCRF2α), and 0.62 nM (mCRF2β)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    171543-83-2
  • Formula Weight
    4707.26
  • Molecular Formula
    C206H338N62O64
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    Sequence:Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Urotensin I

    Urotensin I is, 41-aa neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively. Urotensin-I was first isolated from the urophysis of the white sucker, and has been shown to decrease blood pressure in the rat. UI consists of 41 aa residues with an amidated C-terminus.

  • Verucerfont

    Verucerfont is an antagonist of corticotropin-releasing factor receptor 1 (CRF1) .

  • α-helical CRF 9-41

    Corticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2α and mouse CRF2β receptors respectively).

Sign In Join Free