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SSR125543
CAS No. 752253-39-7
SSR125543( Crinecerfont | SSR-125543 )
Catalog No. M15862 CAS No. 752253-39-7
SSR125543 (Crinecerfont, SSR-125543) is a potent, nonpeptide, orally active corticotropin-releasing factor (CRF) receptor CRF1 antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 264 | Get Quote |
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| 5MG | 404 | Get Quote |
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| 10MG | 593 | Get Quote |
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| 25MG | 888 | Get Quote |
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| 50MG | 1251 | Get Quote |
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| 100MG | 1692 | Get Quote |
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| 500MG | 3402 | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSSR125543
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NoteResearch use only, not for human use.
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Brief DescriptionSSR125543 (Crinecerfont, SSR-125543) is a potent, nonpeptide, orally active corticotropin-releasing factor (CRF) receptor CRF1 antagonist.
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DescriptionSSR125543 (Crinecerfont, SSR-125543) is a potent, nonpeptide, orally active corticotropin-releasing factor (CRF) receptor CRF1 antagonist, shows anxiolytic- and antidepressant-like activities in vivo. Depression Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsCrinecerfont | SSR-125543
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PathwayGPCR/G Protein
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TargetCRF Receptor
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RecptorCRF Receptor
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Research AreaNeurological Disease
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IndicationDepression
Chemical Information
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CAS Number752253-39-7
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Formula Weight483.042
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Molecular FormulaC27H28ClFN2OS
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=C(C=C(C=C1)C(CC2CC2)N(CC#C)C3=NC(=C(S3)C)C4=C(C=C(C(=C4)C)OC)Cl)F
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Chemical Name4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(prop-2-yn-1-yl)-1,3-thiazol-2-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Tildacerfont
Tildacerfont is an antagonist of CRF1 and reduces the levels of adrenocorticotropic hormone and adrenal androgen. Tildacerfont can be used in studies about congenital adrenal hyperplasia.
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K 41498
Potent and highly selective CRF2 receptor antagonist (Ki values are 0.66, 0.62 and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. In rats in vivo, blocks urocortin-induced hypotension following systemic administration.
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Antisauvagine-30
Potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist (Kd values are 1.4 and 153.6 nM for binding to mouse CRF2β and rat CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in HEK-mCRF2β cells (pA2 = 8.49). Prevents stress-enhanced fear conditioning and MEK 1/2-dependent activation of ERK1/2 in mice in vivo.
