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Dolastatin 10
CAS No. 110417-88-4
Dolastatin 10( NSC 376128 | DLS 10 )
Catalog No. M29578 CAS No. 110417-88-4
Dolastatin 10 is a potent antimitotic peptide that inhibits tubulin polymerization.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 132 | In Stock |
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| 10MG | 211 | In Stock |
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| 25MG | 424 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameDolastatin 10
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NoteResearch use only, not for human use.
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Brief DescriptionDolastatin 10 is a potent antimitotic peptide that inhibits tubulin polymerization.
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DescriptionDolastatin 10 is a potent antimitotic peptide that inhibits tubulin polymerization.(In Vitro):Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia. These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI50 values of 10 5-10 6 μg/mL (10 2-10 3 nM) against a similar minipanel of human cell lines. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10.
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In VitroDolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia. These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI50 values of 10?5-10?6 μg/mL (10?2-10?3 nM) against a similar minipanel of human cell lines. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10.
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In Vivo——
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SynonymsNSC 376128 | DLS 10
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetMicrotubule/Tubulin
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RecptorMicrotubule/Tubulin
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Research Area——
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Indication——
Chemical Information
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CAS Number110417-88-4
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Formula Weight785.09
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Molecular FormulaC42H68N6O6S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 100 mg/mL (127.37 mM)
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SMILESCC[C@H](C)[C@@H]([C@@H](CC(N(CCC1)[C@@H]1[C@@H]([C@@H](C)C(N[C@@H](Cc1ccccc1)c1nccs1)=O)OC)=O)OC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C)=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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