Homobutein

Research use only, not for human use.

Homobutein is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities.

Homobutein is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities.(In Vitro):Homobutein (1 μg/mL) inhibits the growth of Toxoplasma gondii by 19.48% with IC50s of 15.0 and 16.1 μM for W2 and D6 strains of P. falciparum. Homobutein (20 - 40 μM) inhibits the viability and TNFα-induced NF-κB activity of K562 cells.

Homobutein (compound 15) (20, 24, 28, 32, 40 μM; 2 h) inhibits the viability of K562 cells.Homobutein (2 h) inhibits TNFα-induced NF-κB activity in K562 cells.Homobutein (1 μg/mL; 72 h) inhibits the growth of Toxoplasma gondii by 19.48%.Homobutein (24 h) againsts W2 and D6 strains of P.falciparum with IC50s of 15.0 and 16.1 μM, respectively.Cell Viability Assay Cell Line:K562 cells Concentration:20, 24, 28, 32, 40 μM Incubation Time:2 h Result:Showed inhibition of viability in K562 cells.Cell Viability AssayCell Line:Toxoplasma gondii RH-2F strain Concentration:1 μg/mL Incubation Time:72 h Result:Surpressed 19.48% of the Toxoplasma gondii.

——

2',4,4'-Trihydroxy-3-methoxychalcone | 3-O-Methylbutein

Others

Antioxidant

Antioxidant

——

——

34000-39-0

286.28

C16H14O5

>98% (HPLC)

——

C(=C/C(=O)C1=C(O)C=C(O)C=C1)\C2=CC(OC)=C(O)C=C2

——

(-20℃)

With Ice Pack

≥ 2 years