Hernandezine( —— )

Catalog No. M29163 CAS No. 6681-13-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Hernandezine
Note

Research use only, not for human use.
Brief Description

Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells.
Description

Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells.(In Vitro):Hernandezine inhibits LPS-induced TNF-α expression/production in human macrophage cell lines (THP-1 and U93). Hernandezine inhibits the transport function of ABCB1, and enhances drug-induced apoptosis in cancer cells. Hernandezine significantly resensitizes ABCB1-overexpressing cancer cells to multiple chemotherapeutic drugs at nontoxic, nanomolar concentrations.
In Vitro

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In Vivo

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Synonyms

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Pathway

Apoptosis
Target

TNF
Recptor

TNF
Research Area

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Indication

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CAS Number

6681-13-6
Formula Weight

652.788
Molecular Formula

C39H44N2O7
Purity

>98% (HPLC)
Solubility

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SMILES

COc1ccc2C[C@@H]3N(C)CCc4c(OC)c(OC)c(OC)c(Oc5cc6[C@H](Cc7ccc(Oc1c2)cc7)N(C)CCc6cc5OC)c34
Chemical Name

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