Bufarenogin( 3beta,12beta,14-Trihydroxy-11-oxo-5beta-bufa-20,22-dienolide )

Catalog No. M29106 CAS No. 17008-65-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Bufarenogin
Note

Research use only, not for human use.
Brief Description

Bufarenogin is a bufadienolide isolated from parotoid gland secretions of the Cuban endemic toad Peltophryne fustiger. Bufarenogin shows anti-tumor activity.
Description

Bufarenogin is a bufadienolide isolated from parotoid gland secretions of the Cuban endemic toad Peltophryne fustiger. Bufarenogin shows anti-tumor activity.(In Vitro):Bufarenogin caused cell death via apoptosis. Bufarenogin induced B-cell lymphoma 2-associated X protein (Bax)-dependent intrinsic apoptosis, as demonstrated by mitochondrial translocation of Bax and cytoplasm release of HCT116 wild-type cells and cytochrome C. Bufarenogin induced intrinsic apoptosis through the cooperation of Bax and adenine-nucleotide translocator and inhibited the metastasis and growth of orthotopical CRC cells.
In Vitro

Bufarenogin induced intrinsic apoptosis through the cooperation of Bax and adenine‐nucleotide translocator and inhibited the metastasis and growth of orthotopical CRC cells.
In Vivo

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Synonyms

3beta,12beta,14-Trihydroxy-11-oxo-5beta-bufa-20,22-dienolide
Pathway

Apoptosis
Target

PERK
Recptor

ERK
Research Area

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Indication

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CAS Number

17008-65-0
Formula Weight

416.514
Molecular Formula

C24H32O6
Purity

>98% (HPLC)
Solubility

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SMILES

[H][C@]12CC[C@]3([H])[C@]([H])(C(=O)[C@@H](O)[C@]4(C)[C@H](CC[C@]34O)c3ccc(=O)oc3)[C@@]1(C)CC[C@H](O)C2
Chemical Name

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