GSK2606414( GSK2606414 | GSK-2606414 | GSK PERK Inhibitor )

Catalog No. M11350 CAS No. 1337531-36-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

GSK2606414
Note

Research use only, not for human use.
Brief Description

GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM.
Description

GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed.(In Vitro):GSK2606414 inhibits PERK activation in cells.(In Vivo):GSK2606414 (50 and 150 mg/kg, p.o.) inhibits the growth of a human tumor xenograft in mice.
In Vitro

GSK2606414 inhibits PERK activation in cells.
In Vivo

GSK2606414 (50 and 150 mg/kg, p.o.) inhibits the growth of a human tumor xenograft in mice.
Synonyms

GSK2606414 | GSK-2606414 | GSK PERK Inhibitor
Pathway

Apoptosis
Target

PERK
Recptor

eIF-2AK1 (HRI)| eIF-2AK2 (PKR)| eIF-2AK3 (PERK)
Research Area

Cancer
Indication

——

CAS Number

1337531-36-8
Formula Weight

451.44
Molecular Formula

C24H20F3N5O
Purity

>98% (HPLC)
Solubility

Ethanol: 19 mg/mL (42.08 mM); DMSO: 90 mg/mL (199.36 mM)
SMILES

FC(C1=CC(CC(N2CCC3=C2C=CC(C4=CN(C)C5=NC=NC(N)=C54)=C3)=O)=CC=C1)(F)F
Chemical Name

1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)indolin-1-yl)-2-(3-(trifluoromethyl)phenyl)ethanone

1.Axten JM, et al. J Med Chem. 2012, 55(16), 7193-7207.

Calculator

molnova catalog